Chronic Cancer Pain Research

Request for Proposal

Artwork Not Giving Up has been created as part of our Patient Arts for Health Global Exhibition.

This RFP was designed based on patient needs. It will focus on interventions for the prevention and/or treatment of cancer-related chronic pain. Specifically, the RFP welcome proposals focused on all types of cancer-related chronic pain, including but not limited to post-surgical pain, lymphedema-related pain, chemotherapy-induced peripheral neuropathy, phantom pain, aromatase inhibitor-related joint pain, referred pain and bone metastasis pain.

Research Topics

We welcome applications for interventional clinical trials focusing on: 

  • Increasing the use of integrative medicine through evidence. 
  • Repurposing of off-patent compounds.

Study outcomes should include well-validated clinical and patient-reported outcomes. We encourage trials that include adult, geriatric, or pediatric populations. Phase II or III clinical trials are strongly encouraged. Other well-designed studies, such as comparative effectiveness trials, may be considered. 

Please note that interventions including dietary products are not eligible for this RFP. 


RTFCCR will grant up to 2 million dollars in 2024. The awards will be selected in a competitive manner and will be of two kinds: 

  • Pilot studies worth $50,000-$100,000 (100% funding from RTFCCR) 
  • Large scale clinical trials, where RTFCCR’s contribution is capped between $200,000 to $1,000,000 (RTFCCR provides up to a maximum of 50% of the clinical trial total cost) 

Patient Involvement in Research

We define patient involvement as meaningful involvement of patients in the development of detection, therapeutic, or symptom management approaches. It encompasses the active, meaningful, and collaborative interaction between patients and researchers across all stages of the research process, where research decision-making is guided by patients’ contributions as partners, recognizing their specific experiences, values, and expertise. 

We adopt the definition of patient partner provided by Patient-Centered Outcomes Research Institute (PCORI). PCORI’s definition of patient partners includes patients (those with lived experience), family members, caregivers, and the organizations that are representative of the population of interest in a particular study. 

It is important that patient partners are not confused with trial participants; patient partners are members of the research team and involved in the planning, conducting, and dissemination of the research, whereas trial participants are those individuals enrolled in the study. 

The strategy, modalities, and budgets for patient involvement, related deliverables, and expected outcomes are to be included in the grant budget and must be clearly described in the grant application. Please refer to our funding guidelines for more information.

How to apply

1) Letter of Intent deadline - July 9, 2024

We receive Letter of Intent (LOIs) through our online grant management platform SmartSimple (SmartSimple | Rising Tide Foundation). LOIs will be assessed by internal staff and advisory board members. The most promising LOIs aligning with this request for proposal topics will be invited to submit a full grant application.

2) Full Proposal deadline - September 10, 2024

Selected LOIs will be invited for full application submission. Full grant applications are submitted through SmartSimple and reviewed by our Grant Review Committee (GRC), a panel of external experts conducting a comprehensive scientific review. Each application will be independently analyzed and ranked by the scientific peer reviewers, patient experts and a biostatistician on the panel. Recommendations made by the Grant Review Committee and RTFCCR Advisory Board will then be submitted to the Rising Tide Board of Directors in December 2024 for final funding approval.

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