Implementation Research
There is an unmet need to produce evidence on whether or not an approach is being adopted by clinicians and patients, especially with so many patients being treated with oral medication and in outpatient clinics.
An effectiveness-implementation hybrid design is one that takes a dual focus a priori in assessing clinical effectiveness and implementation.
We welcome grant applications that use one of the 3 hybrid types (described below) applied to clinical research under our Focus Areas.
| Study Characteristics | Hybrid Trial Type 1 | Hybrid Trial Type 2 | Hybrid Trial Type 3 |
|---|---|---|---|
| Research aims | Primary aim: determine effectiveness of a clinical intervention Secondary aim: better understand context for implementation | Coprimary aim*: determine effectiveness of a clinical intervention Coprimary aim: determine feasibility and potential utility if an implementation intervention/strategy | Primary aim: determine utility of an implementation intervention/strategy Secondary aim: assess clinical outcomes associated with implementation trial |
| Research questions (examples) | Primary question: will a clinical treatment work in this setting/these patients? Secondary question: what are potential barriers/facilitators to a treatment's widespread implementation? | oprimary question*: will a clinical treatment work in this setting/these patients? Coprimary question: does the implementation method show promise (either alone or in comparison with another method) in facilitating implementation of a clinical treatment? | Primary question: which method works better in facilitating implementation of a clinical treatment? Secondary question: are clinical outcomes acceptable? |
Exerpt from: Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012 Mar;50(3):217-26. doi: 10.1097/MLR.0b013e3182408812. PMID: 22310560; PMCID: PMC3731143.
Hybrid Type 1
Testing a clinical intervention while gathering information on its delivery during the effectiveness trial and/or on its potential for implementation in a real-world situation.
Hybrid Type 2
Simultaneous testing of a clinical intervention and an implementation intervention/strategy.
Hybrid Type 3
Testing an implementation intervention/strategy while observing/gathering information on the clinical intervention and related outcomes.
Funding Opportunities
Open Call
We accept Letters of Intent (LOIs) all year round with cutoff deadlines for internal assessment three times per year. Once you have submitted your LOI, you will receive further information regarding timing and next steps.
Pre-application Grants
Pre-application grants provide gap funding to support patient experts’ helping to develop grant applications/ protocols.
Focus Area Grants
University of Texas M.D. Anderson Cancer Center
