Science of Early Intervention

In this Focus Area we support interventional clinical trials exploring novel therapeutic approaches to intervene on precursors or early cancer stages, interfering with their potential development towards more aggressive cancer stages.

  • A tumor originates within normal tissues, when one or more cells experience aberrant genetic events and start proliferating in an uncontrolled manner
  • This change in cell behavior is caused by a genetic event (a mutation). The cause of the cancer-causing mutation can be sporadic or due to environmental factors (carcinogens, UV etc)
  • These abnormally growing cells (dysplasia) can develop into a mass (in situ) that can start interacting with the surrounding cells (tissue microenvironment).
  • The in situ tumor and can further develop, becoming an invasive tumor. Through cell signaling, the tumor stimulates capillary growth, to have access to nutrients in the blood.  Moreover, it also convinces the body immune system (lymphocytes and macrophages) to support its growth instead of fighting it.
  • When the change in cell behavior reaches a certain stage, it can be detected, and interventions can be employed to eradicate it.
  • In some cases, the intervention (e.g., neo-adjuvant, chemotherapy, radiotherapy, surgery, adjuvant treatments) does not eradicate the tumor completely: some cells can be left behind and, with time, begin proliferating again, resulting in tumor recurrence /relapse.
  • Sometimes before, during or after treatment, the tumor can shed living cells in blood or lymphatic vessels, which can move to colonize other tissues (metastasis) 

The Rising Tide Foundation for Clinical Cancer Research (RTFCCR) seeks to support Phase I to Phase III clinical trials across different stages of the cancer journey, with specific focus on the following strategic focus areas:

  • Science of Early Detection and Intervention, where support is provided for clinical trials aimed at detecting abnormal cells at the earliest time possible and intervening to eliminate them before they can develop into more aggressive tumor stages.
  • Improved Patient Outcomes, where support is provided for interventional clinical trials that advance therapeutic approaches with the best possible outcomes and the least toxicity

Funding Opportunities

Open Call

We accept Letters of Intent (LOIs) all year round with cutoff deadlines for internal assessment three times per year. Once you have submitted your LOI, you will receive further information regarding timing and next steps.

Pre-application Grants

Pre-application grants provide gap funding to support patient experts’ helping to develop grant applications/ protocols.

Request for Proposal

At the moment there are no other open funding opportunities.

Focus Area Grants

Cleveland Clinic Foundation

Development of Alternative Ablation Device

Science of Early Intervention Materials

Hallmarks of Cancer - Cell

Focus Areas

Science of Early Detection and Intervention

Advancing Cancer Research in Underserved Areas

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