Dr. Steven Rosen
Organization: City of Hope
Project Name: A Phase I/II Trial of 8-Chloro-adenosine in Relapsed or Refractory Acute Myeloid Leukemia
Funding Year: 2015
Project period: 6 years
A Phase I/II Trial of 8-Chloro-adenosine in Relapsed or Refractory Acute Myeloid Leukemia
This phase I/II trial will assess the safety and efficacy of 8-Chloro-Adenosine (8-Cl-Ado), a new therapeutic small molecule that is preferentially toxic to cancer as opposed to normal cells. It has shown potent anticancer activity against leukemia cells and has been very well tolerated in an earlier human clinical trial evaluating safety for different blood cancer.