A Phase I/II Trial of 8-Chloro-adenosine

Grant Details

Grantee Name:
 Dr. Christine Brown
Organization: City of Hope

Country: USA

Project Name:
 A Phase I/II Trial of 8-Chloro-adenosine in Relapsed or Refractory Acute Myeloid Leukemia
Funding Year: 2017

Project period: 4 years

A Phase I/II Trial of 8-Chloro-adenosine in Relapsed or Refractory Acute Myeloid Leukemia

The central hypothesis is that CAR T cells targeting cell surface antigens will eradicate diffuse tumor cell populations. This hypothesis will be tested in phase I clinical trial in 11 patients over a duration of four years. The study will assess the safety and determine the recommended phase II dosing plan for loco-regional administration in 3 routes.

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