Targeting eIF4A in melanoma persistent cells

Grant Details

Grantee Name:
 Dr. Caroline Robert
Organization:
 Gustave Roussy Institute
Country: France

Project Name:
 Targeting eIF4A in melanoma persistent cells to prevent resistance
Funding Year:
 2018
Project period: 3 years

Targeting eIF4A in melanoma persistent cells to prevent resistance

By combining BRAF+MEK inhibitors with eIF4A inhibitors the team has managed to kill the persistent cells and prevent the emergence of mutant resistant clones in vitro. The objective of this grant is to translate this strategy to the clinic.

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