Dr. Zev Nakamura
Organization: University of North Carolina at Chapel Hill
Project Name: Thiamine for Delirium Prevention in Hematopoietic Stem Cell Transplantation
Funding Year: 2017
Project period: 3 years
Thiamine for Delirium Prevention in Hematopoietic Stem Cell Transplantation
Examine the effects of high dose IV thiamine as prophylaxis for delirium. Evaluate its effects on quality of life and neuropsychiatric sequelae of delirium.
High doses of IV thiamine have been studied in oncologic populations with promising results when used as a treatment strategy for delirium, but it is generally employed late in the course of delirium and it remains unknown if it can mitigate the long-term impact of delirium on cancer patients.
The project proposes a double-blind randomized controlled trial (RCT) with a total of 60 patients.