High fiber diet to enhance the microbiome in immunotherapy

Grant Details

Grantee Name: Jennifer Leigh McQuade
Organization: University of Texas M.D. Anderson Cancer Center
Country: United States

Focus Area: Therapy Optimization
Funding Year: 2019
Funding Scheme: Seerave Foundation
Project period: 3 years

Patient outcomes in metastatic melanoma, the most deadly of common skin cancers, have improved dramatically with the approval of immune checkpoint inhibitors (ICI). Nonetheless, not all patients benefit from these therapies and actionable strategies to enhance the effectiveness of ICI are urgently needed. This study seeks to develop a deeper understanding of the role of a whole foods, plant-based, fiber-rich diet on the microbiome and anti-tumor immunity in patients receiving immunotherapyTo test the impact of a whole food, high-fiber diet on systemic and anti-tumor immunity in patients with metastatic melanoma on anti-PD1.

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